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Important Risk Information

  • Some patients taking ZURAMPIC may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). This is more common when ZURAMPIC is taken without a xanthine oxidase inhibitor such as allopurinol or Uloric
  • ZURAMPIC should always be taken with a xanthine oxidase inhibitor

Do not take ZURAMPIC if you have severe kidney problems, have received a kidney transplant or are on dialysis, have a fast breakdown of cancer cells that can lead to high uric acid (tumor lysis syndrome), or have a rare inherited condition that causes too much uric acid in the blood (Lesch-Nyhan syndrome).

Before taking ZURAMPIC, tell your doctor about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZURAMPIC may affect the way other medicines work, and other medicines may affect how ZURAMPIC works.

ZURAMPIC may cause serious side effects including heart problems. People who take ZURAMPIC can have serious heart problems, including heart attack and stroke. It is not known that ZURAMPIC causes these problems.

The most common side effects of ZURAMPIC are headache, flu, higher levels of blood creatinine (a measure of kidney function), and heartburn.

Tell your doctor if you have any side effects that bother you or that do not go away. These are not all of the possible side effects of ZURAMPIC.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

For more information, ask your doctor or pharmacist.

ZURAMPIC is a prescription medicine used together with a xanthine oxidase inhibitor such as allopurinol or Uloric in adults with gout who still have a high uric acid level.

Please see Medication Guide within full Prescribing Information, including BOXED WARNING.